TRANSCELLULAR METABOLISM OF LEUKOTRIENE A4 BY RABBIT BLOOD CELLS: LACK OF RELEVANT LTC4-SYNTHASE ACTIVITY IN RABBIT PLATELETS

Transcellular metabolism of leukotriene A4 by rabbit blood cells: lack of relevant LTC4-synthase activity in rabbit platelets

The objective of this study was to determine the transcellular metabolism of leukotriene A4 by rabbit blood cells.mixed peripheral blood leukocyte preparations with and without platelets in a ratio of 1:40 were challenged with the Ca(2+)-ionophore A23187.5-Lipoxygenase metabolites production was assessed by RP-HPLC coupled with diode-array UV detec

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Future clinical trials in DIPG: bringing epigenetics to the clinic

In spite of major recent advances in DIPG molecular characterization, this body of knowledge has not yet translated into better treatments.To date,more than 250 clinical trials evaluating radiotherapy along with conventional cytotoxic chemotherapy as well as newer biologic agents,have failed to improve the dismal outcome when Nourshing Shampoo comp

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